Pain in the legs can occur as a result of conditions that affect bones, joints, muscles, tendons, ligaments, blood vessels, nerves, or skin. Typically, the pain is a result of tissue inflammation that is caused by injury or disease. Either injury or chronic disease can cause inflammation to any of the tissues of the leg and lead to leg pain. Since the leg contains a number of different structures and tissue types, a wide variety of conditions and injuries can cause leg pain. Depending on the cause of the pain, other symptoms, like weakness, numbness, or a tingling sensation, may accompany leg pain. Diabetic neuropathy (nerve damage) is a common cause of tingling and numbness in the legs that can at times be painful. For diagnostic and therapeutic purposes, it is important to differentiate the exact type and location of any pain in the legs. Blood clots (deep vein thrombosis) can be another cause of leg pain. Pain in the knee and ankle joints of the leg is common with the arthritis conditions.